The NIMH Center for Global Mental Health Research (CGMHR) and Grand Challenges Canada co-convened the 10th anniversary global mental health conference, April 8-9, 2019, on the main campus of the National Institutes of Health. More than 400 researchers, innovators, and other stakeholders from 36 countries attended the two-day conference, where they learned about findings from cutting-edge science and new opportunities for groundbreaking research to address the Grand Challenges In Global Mental Health.